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. 2015 Feb 25;17(1):27. doi: 10.1186/s13058-015-0529-8

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© Singh et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The dose–response curves of the lead compounds did not shift in the presence of higher concentrations of oestradiol. (A) Dose–response curves (0.000095 to 50 μM) of 4-hydroxytamoxifen (OHT) showing a rightward shift proportional to the fold increase in concentrations of oestradiol (E2) generated by the luciferase assay in the T47D-KBluc cell line. Dose–response curves (0.1 to 50 μM) of (B) VPC-16225 and VPC-16230 (C) showing no significant rightward shift in the presence of higher concentrations of E2 as measured by luciferase assay in the T47D-KBluc cell line. Error bars indicate standard error of mean for n = 6 values. Data were fitted using GraphPad Prism 5 to calculate the log of concentration of the inhibitors versus percentage activation.