Table I.
Characteristics of 5 children with SCD who presented with acute splenic sequestration crisis in association with acute parvovirus infection.
| Patient | Genotype | Age (years) |
Baseline Hb (gm/dL) |
Lowest Hb (gm/dL) |
Absolute Reticulocytes (X 109/L) |
Reticulocytes (%) |
Baseline Platelets (X 109/L) |
Lowest Platelets (× 109/L) |
Largest Spleen Size |
Follow-up Spleen Size |
Parvovirus IgM (positive >1.1) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | HbSS on hydroxyurea |
3 | 9.2 | 3.7 | 2 | 0.1 | 130 | 48 | 6 cm | 0.5 cm | 13.4 |
| 2 | HbSC | 8 | Unknown* | 4.3 | 5 | 0.2 | Unknown* | 108 | 4 cm | 2 cm | 14.7 |
| 3 | HbSC | 15 | 11.4 | 3.9 | 3 | 0.1 | 233 | 40 | 7 cm | Non-palpable | 13.7 |
| 4 | HbSC | 11 | 10.3 | 3.9 | 8 | 0.4 | 130 | 85 | 10 cm | Splenectomy | 13.3 |
| 5 | HbSC | 6 | 10.4 | 4.2 | 6 | 0.4 | 276 | 100 | 10 cm | Splenectomy | 9.4 |
Spleen size refers to distance below the left costal margin.
*
First presentation to our institution.