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. Author manuscript; available in PMC: 2015 Jun 10.
Published in final edited form as: Sci Transl Med. 2014 Dec 10;6(266):266ra170. doi: 10.1126/scitranslmed.3010189

Fig 5. Lack of protective effect of VIS nor DPU on tumor cells in vitro or in vivo.

Fig 5

Cell viability in multiple tumor lines including DU145 (A), LNCaP (B), MCF7 (C) and MDA-MB-231 (D) treated with VIS or DPU.. (E) Fold change in size of xenografted human tumor derived from Jurkat cell injection in zebrafish in vivo treated with either VIS or DPU. (F) Tumor volume in human tumor xenograft derived from injected MDA-MB-231 cells in mice treated with doxorubicin and VIS. Tumor size was assessed by caliper measurement of long axis a, short axis b and was calculated with equation V=1/2*a*b2. n = 8 mice in each group. (G) Representative images of postmortem tumors from the three groups. (H) Effect of VIS on Dox inhibition of tumor growth.Cont – vehicle treated control samples, Dox – doxorubicin treated samples, Dox + VIS – doxorubicin and VIS co-treated samples, Dox + DPU – doxorubicin and DPU co-treated samples. NS, non-significant. Statistics (compared to doxorubicin treated samples): * p< 0.05, ** p<0.01, and *** p<0.001.