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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Ann N Y Acad Sci. 2014 Mar 21;1327:1–26. doi: 10.1111/nyas.12388

Table 2. Effects of pharmacological manipulations of monoaminergic signaling on inhibitory response control.

Upwards arrows indicate that the manipulation increased impulsive responding in the test, while downwards arrows indicate a reduction in impulsive responding in the test. Effects are drawn from studies cited in Section 2.5., 3.5., and 4.4. of the text.

Serotonin Dopamine Norepinephrine
Depletion Reuptake inhibition -2A antagonist -2C antagonist D2 antagonist Reuptake inhibition
Action Inhibition Stop signal reaction time task No change No change Not done Not done graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg
Reversal learning graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg
Waiting 5CSRTT graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg graphic file with name nihms669333t2.jpg graphic file with name nihms669333t1.jpg Variable graphic file with name nihms669333t2.jpg
DRL graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg graphic file with name nihms669333t2.jpg Not done Not done graphic file with name nihms669333t2.jpg
Delay-related decision making Delay discounting graphic file with name nihms669333t1.jpg graphic file with name nihms669333t2.jpg Not done Not done Variable graphic file with name nihms669333t2.jpg
Risk-related decision making Gambling tests graphic file with name nihms669333t1.jpg No change Not done Not done Variable No change