Table 2.
Risk of All-Cause Mortality: Univariate Analysis of Overall Survival
| Seven-year survival rate±standard error | Unadjusted hazard ratioa | 95% CI | p Valuea | |
|---|---|---|---|---|
| Gender | ||||
| Male (reference) vs. | 67%±5% | |||
| Female | 80%±8% | 0.58 | (0.23, 1.48) | 0.257 |
| Drug use | ||||
| No [reference] | 73%±6% | |||
| Yes | 66%±6% | 1.3 | (0.69, 2.45) | 0.413 |
| Heavy alcohol use | ||||
| No [reference] | 74%±5% | |||
| Yes | 58%±8% | 1.7 | (0.90, 3.25) | 0.100 |
| Type of infection | ||||
| HIV/HBV [reference] | 78%±6% | |||
| Triple (HIV/HBV/HCV) | 69%±7% | 1.32 | (0.60, 2.89) | 0.492 |
| HIV/HCV | 55%±9% | 2.17 | (1.03, 4.55) | 0.041b |
| Baseline APRI score | ||||
| APRI <0.5 [reference] | 76%±5% | |||
| APRI 0.5–1.5 (indeterminate) | 70%±8% | 1.17 | (0.54, 2.53) | 0.69 |
| APRI >3.25 | 39%±12% | 2.79 | (1.32, 5.91) | 0.007b |
| Baseline FIB-4 score | ||||
| FIB-4 <1.45 | 75%±6% | |||
| FIB-4 1.45–3.25 | 72%±7% | 1.02 | (0.47–2.18) | 0.96 |
| FIB-4 >3.25 | 36%±13% | 3.83 | (1.68–8.77) | 0.002b |
| Change in APRI score | n/a | 1.14 | 1.02–1.28 | 0.020b |
| Change in FIB-4 score | n/a | 1.03 | 1.01–1.04 | <0.001b |
a
Hazard ratios and p values based on univariate Cox proportional hazards regression model.
b
p Value<0.05 statistically significant.
CI, confidence interval; n/a, not applicable since this is a continuous variable; HBV, hepatitis B virus; HCV, hepatitis C virus; APRI, aspartate aminotransferase/platelet ratio index.