Table 1.

Summary of ΔpHi, ΔpHe and ΔβNTP/Pi of human tumor xenografts measured by ³¹P MRS following LND treatment.

Parameter	DB-1 melanoma Xenografts (n = 15)	BT-474 breast cancer xenografts (n = 3)	HCC1806 breast cancer xenografts (n = 3)	A2780 ovarian cancer xenografts (n = 3)	LNCaP prostate cancer xenografts (n = 3)
ΔpHi	0.60 ± 0.1 P < 0.05	0.44 ± 0.14 P = 0.05	0.54 ± 0.23 P < 0.05	0.56 ± 0.10 P < 0.05	0.47 ± 0.11 P < 0.05
ΔpHe	0.20 ± 0.07 P < 0.05	0.22 ± 0.07 P = 0.05	0.28 ± 0.19 P = 0.05	0.34 ± 0.23 P = 0.05	0.30 ± 0.13 P > 0.05
ΔβNTP/Pi	66.8 ± 5.7% P < 0.05	70.0 ± 0.12% P < 0.05	77.0 ± 0.09% P < 0.05	70.0 ± 0.22% P < 0.05	77.5 ± 0.04% P < 0.05

NOTE: The pH values were determined by ³¹P MR spectroscopy as described in “Materials and Methods” pHi, pHe and βNTP/Pi represent intracellular pH, extracellular pH and bioenergetics, respectively. Time interval was 2 hr for LNCaP prostate cancer xenografts and 3 hr for other tumor types. Data are presented as mean ± S.E.M.