The intracellular pH (pHi) profile as a function of time of (A) skeletal muscle (n=3), (B) brain (n=3), (C) surgically exposed liver (n=3), and extracellular pH (pHe) profile as a function of time of (D) surgically exposed liver (n=3) and (E) skeletal muscle (n=3) in response to LND (100 mg/kg; i.p.) administration at time zero after 20 min i.v. infusion of glucose (26 mM). The data for experiments without glucose infusion, previously published in (7) and depicted by open squares, are included for direct comparison. Baseline measurements for glucose infusion studies were performed at −20 min, up to 100 min for duration of 120 min whereas, baseline without the addition of exogenous and before LND administration were done at 0 min. The values are presented as mean ± S.E.M. When not displayed, S.E.M. values were smaller than the symbol size.