Table 1.
Univariate Analysis of clinicopathologic features with final excisional diagnosis (CFA and BPT)
| PT (N=27) |
CFA (N=37) |
Total (N=64) |
p value |
C-
statistic |
|
|---|---|---|---|---|---|
| Age | 0.98071 | 0.51 | |||
| Mean (SD) | 40.7 (15.3) | 40.6 (14.5) | 40.7 (14.7) | ||
| Range | (18.0-69.0) | (15.0-83.0) | (15.0-83.0) | ||
| Tumor size | 0.02931 | 0.70 | |||
| Mean (SD) | 2.9 (2.2) | 1.8 (1.1) | 2.2 (1.7) | ||
| Median | 2.3 | 1.5 | 1.8 | ||
| Q1, Q3 | 1.5, 3.5 | 1.0, 2.2 | 1.1, 2.7 | ||
| Range | (0.8-12.0) | (0.6-5.4) | (0.6-12.0) | ||
| Mitoses per 10hpf | <0.00011 | 0.83 | |||
| Mean (SD) | 3.0 (1.7) | 0.8 (1.3) | 1.8 (1.8) | ||
| Median | 3.0 | 0.0 | 1.0 | ||
| Q1, Q3 | 2.0, 4.0 | 0.0, 1.0 | 0.0, 3.0 | ||
| Range | (0.0-6.0) | (0.0-5.0) | (0.0-6.0) | ||
| Mitoses: categorical | <0.00013 | 0.83 | |||
| 0 (/10 HPF) | 4 (14.8%) | 22 (59.5%) | 26 (40.6%) | ||
| 1-2 (/10 HPF) | 3 (11.1%) | 11 (29.7%) | 14 (21.9%) | ||
| ≥3/10 HPF | 20 (74.1%) | 4 (10.8%) | 24 (37.5%) | ||
| Mitoses (<=2 versus >=3) | <0.00013 | 0.82 | |||
| 0-2 (/10 HPF) | 7 (25.9%) | 33 (89.2%) | 40 (62.5%) | ||
| ≥3 (/10 HPF) | 20 (74.1%) | 4 (10.8%) | 24 (37.5%) | ||
| Stromal Overgrowth | 0.00042 | 0.69 | |||
| Missing | 1 | 0 | 1 | ||
| Absent (0) | 15 (57.7%) | 35 (94.6%) | 50 (79.4%) | ||
| Present (1) | 11 (42.3%) | 2 (5.4%) | 13 (20.6%) | ||
| Increased Stromal cellularity | 0.38773 | 0.55 | |||
| Absent (0) | 1 (3.7%) | 5 (13.5%) | 6 (9.4%) | ||
| Present (1) | 26 (96.3%) | 32 (86.5%) | 58 (90.6%) | ||
| Stromal Fragmentation | 0.00113 | 0.70 | |||
| Absent (0) | 3 (11.1%) | 19 (51.4%) | 22 (34.4%) | ||
| Present (1) | 24 (88.9%) | 18 (48.6%) | 42 (65.6%) | ||
| Infiltration into fat | 0.00582 | 0.66 | |||
| Absent (0) | 14 (51.9%) | 31 (83.8%) | 45 (70.3%) | ||
| Present (1) | 13 (48.1%) | 6 (16.2%) | 19 (29.7%) | ||
| Stromal Heterogeneity | 0.00022 | 0.73 | |||
| Absent (0) | 8 (29.6%) | 28 (75.7%) | 36 (56.3%) | ||
| Present (1) | 19 (70.4%) | 9 (24.3%) | 28 (43.8%) | ||
| Subepithelial Condensation | 0.00012 | 0.73 | |||
| Absent (0) | 10 (37.0%) | 31 (83.8%) | 41 (64.1%) | ||
| Present (1) | 17 (63.0%) | 6 (16.2%) | 23 (35.9%) | ||
| Stromal pleomorphism | 0.00102 | 0.71 | |||
| Absent (0) | 7 (25.9%) | 25 (67.6%) | 32 (50.0%) | ||
| Present (1) | 20 (74.1%) | 12 (32.4%) | 32 (50.0%) | ||
|
Combined histologic features excluding
mitotic activity (of 7 possible from above) |
<0.00011 | 0.94 | |||
| Mean (SD) | 3.9 (1.2) | 1.4 (1.0) | 2.5 (1.6) | ||
| Median | 4.0 | 1.0 | 2.0 | ||
| Q1, Q3 | 3.0, 5.0 | 1.0, 2.0 | 1.0, 4.0 | ||
| Range | (2.0-6.0) | (0.0-4.0) | (0.0-6.0) | ||
|
Combined histologic features excluding
mitotic activity, categorized |
<0.00012 | 0.88 | |||
| 0-2 features | 4 (14.8%) | 33 (89.2%) | 37 (57.8%) | ||
| 3-7 features | 23 (85.2%) | 4 (10.8%) | 27 (42.2%) | ||
1
Unequal Variance T-Test
2
Chi-Square
3
Fisher Exact
Histologic features include: stromal mitotic activity, stromal overgrowth, increased stromal cellularity, stromal fragmentation, infiltration into fat, stromal heterogeneity, subepithelial stromal condensation, and stromal nuclear pleomorphism/cellular atypia