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. Author manuscript; available in PMC: 2016 Mar 2.
Published in final edited form as: Curr Protoc Pharmacol. 2015 Mar 2;68:2.12.1–2.12.26. doi: 10.1002/0471141755.ph0212s68

Fig. 3. Arrestin-3 mediated JNK1/2 activation by MKK4/7.

Fig. 3

In vitro phosphorylation of JNK1α1 and JNK2α2 in the presence of MKK4 (A) or MKK7 (B) yielded bell-shaped curves as functions of arrestin-3 concentration. Means ± SD of three independent experiments are shown. ANOVA analysis with arrestin-3 as main factor demonstrated significance of arrestin-3 concentration in the presence of MKK4 and MKK7 for both JNK1α1 and JNK2α2 (p<0.001). * - p<0.001, ** - p<0.01, * - p<0.05 to maximal values (at 5 or 10 μM of arrestin-3, respectively) according to Bonferroni/Dunn post-hoc test with correction for multiple comparisons. Data from (Kook et al., 2014).