Table 6. Transfection to determine ASK1- and arrestin-3-dependent JNK activation.
pcDNA3-HA-ASK1 | 0 μg | 0.05 μg | 0.1 μg | 0.25 μg | 0.5 μg | 1 μg | 1.5 μg |
pcDNA3 | 1.5 μg | 1.45 μg | 1.4 μg | 1.25 μg | 1.0 μg | 0.5 μg | 0 μg |
pcDNA3-arrestin-3 | 0.5 μg | 0.5 μg | 0.5 μg | 0.5 μg | 0.5 μg | 0.5 μg | 0.5 μg |
FuGENE HD | 6μl | 6μl | 6μl | 6μl | 6μl | 6μl | 6μl |
Opti-MEM | 125μl | 125μl | 125μl | 125μl | 125μl | 125μl | 125μl |
Note: For MKK7 induced JNK activation, add pcDNA3-Flag-MKK7β1 instead of pcDNA3-HA-ASK1.