Table 4.
Association of family history and number of primaries with prevalence of CDKN2A mutations
| Australia | Spain | UK | Total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictor | No./total cases 1 | % | OR 2 (95% CI) | No./total cases | % | OR (95% CI) | No./total cases | % | OR (95% CI) | % | Multivariate OR 3 |
| Family history 4 | |||||||||||
| 0 | 7/500 | 1.4 | 1.0 | 13/696 | 1.9 | 1.0 | 20/1470 | 1.4 | 1.0 | 1.5 | 1.0 |
| 1 | 4/76 | 5.3 | 3.9 (1.1, 13.7) | 3/35 | 8.6 | 4.9 (1.3, 18.2) | 4/101 | 4.0 | 3.0 (1.0, 8.9) | 5.2 | 3.8 (1.9, 7.5) |
| 2+ | 3/20 | 15.0 | 12.4 (3.0, 52.3) | 3/16 | 18.8 | 12.1 (3.1, 47.7) | 7/15 | 46.7 | 63.4 (21.0, 19.8) | 25.5 | 23.2 (11.3, 47.6) |
| No. of primaries 5 | |||||||||||
| 1 | 14/581 | 2.4 | n/a | 8/644 | 1.2 | 1.0 | 20/1495 | 1.4 | 1.0 | 1.3 | 1.0 |
| 2 | 0/14 | 0 | 6/80 | 7.5 | 6.5 (2.2, 19.1) | 4/73 | 5.5 | 4.3 (1.4, 12.9) | 6.5 | 5.4 (2.5, 11.6) | |
| 3+ | 0/1 | 0 | 5/23 | 21.7 | 22.1 (6.6, 74.2) | 7/18 | 38.9 | 46.9 (16.5, 133.5) | 29.3 | 32.4 (14.7, 71.2) | |
1Number of cases with a pathogenic CDKN2A mutation/the total number of cases.
2Unadjusted odds ratio.
3“Family history” analysis ORs adjusted for presence of MPM, age at diagnosis and country; “Number of primaries” analysis adjusted for family history, sex, age at diagnosis and country.
4Number of first or second degree relatives with melanoma.
5Number of primary melanomas diagnosed in the case. Few MPMs were observed for the Australian cases due to the study design.