Table I.
Cell numbers in lymphoid tissues following B cell depletion
| Cell Type | Tissue | 2H7 | mlgG |
|---|---|---|---|
| Total cells (× 106) | SPL | 37.88 ± 8.11 | 83.63 ± 3.68b |
| MLN | 2.78 ± 0.76 | 7.830 ± 0.40c | |
| PLN | 1.03 ± 4.24 | 4.73 ± 8.75a | |
| Vβ4+CD4+ T cells (× 106) | SPL | 17.61 ± 3.77 | 22.58 ± 0.99 |
| MLN | 2.67 ± 0.12 | 3.61 ± 0.18a | |
| PLN | 0.75 ± 0.31 | 1.84 ± 0.34 | |
| B220+IgM+ B cells (× 106) | SPL | 6.42 ± 1.38 | 49.34 ± 2.17c |
| MLN | 0.06 ± 0.003 | 1.30 ± 0.065c | |
| PLN | 0.02 ± 0.01 | 0.85 ± 0.16b |
Mice were sacrificed after B cell depletion. Values (mean ± SEM) indicate cell number (× 106) present in each tissue (n = 5/group).
a
p < 0.05.
b
p < 0.01.
c
p < 0.001, significant differences between 2H7-treated versus control mIgG-treated mice.