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. 2015 Mar 16;10(3):e0119411. doi: 10.1371/journal.pone.0119411

Fig 3. KA-SE increased bursting preferentially in mature rats.

Fig 3

A, B. Top: Effects of KA on the proportions of strong-bursting (SB), weak-bursting (WB), and regular-spiking neurons in immature (P15) rats injected with saline (black) or KA (red) and measured early (A) or late (B) time point. Bottom: Effects of KA-SE on frequency-dependent bursting in the same groups of animals. C, D. Similar data obtained from mature animals injected with saline or KA and measured early (C) or late (D) after KA-SE. #Burst-frequency curve for KA is significantly different from control, p<0.01 (two-way ANOVA). The total number of bursts in the mature, late group (KA versus control) is also significant when a single value (average of all cells) is compared from each injected animal, p<0.05 (unpaired Student’s t-test). No other curves are significantly different. The apparent appearance of difference in the proportion of cells belonging to bursting and regular spiking in two groups of control neurons, P15,36 (B) versus P30,36 (C) shown on top panels were not statistically significant (P15, 36 Control: SB + WB = 16, RS = 6; versus P30 36 Control: SB+WB = 36, RS = 2, Fisher’s exact test, p = 0.17).