Table 2.

The cross-sectional association between B12 (OR per 1SD increase log Vitamin B12) and prevalent albuminuria and RKF at Offspring Examination 6

			Model 1			Model 2			Model 3
	n	Events (%)	OR	CI	p-value	OR	CI	p-value	OR	CI	p-value
Entire Cohort
Albuminuria	2965	523 (17.6)	1.25	0.98-1.60	0.07	1.25	0.97-1.61	0.08	1.44	1.10-1.87	0.008
RKF	3451	319 (9.2)	0.99	0.72-1.35	0.94	0.98	0.72-1.35	0.92	1.83	1.30-2.59	<0.001
Stratified analysis: Albuminuria*
Homocysteine < median	1511	228 (15.1)	1.28	0.87-1.88	0.21	1.29	0.87-1.91	0.21	1.27	0.85-1.90	0.24
Homocysteine ≥ median	1454	295 (20.3)†	1.45	1.03-2.03	0.03	1.41	0.99-2.01	0.06	1.57	1.10-2.26	0.01
Stratified analysis: RKF*
Homocysteine < median	1722	70 (4.1)	0.90	0.47-1.75	0.76	0.92	0.47-1.78	0.80	1.22	0.62-2.41	0.56
Homocysteine ≥ median	1729	249 (14.4)†	1.62	1.10-2.37	0.01	1.57	1.06-2.31	0.02	2.17	1.44-3.26	<0.001

Model 1: Age- and sex- adjusted.

Model 2: Multivariable-adjusted: Albuminuria - systolic blood pressure, HDL_c, smoking status, hypertension treatment and diabetes.

RKF: diabetes, hypertension and dipstick proteinuria.

Model 3: Multivariable-adjusted + baseline log homocysteine.

*Stratified by the median homocysteine levels (9.08 μmol/L).

^†p-value <0.001 for comparison.