Table 1.

Features for combination detection. Each feature is labeled with its field in AACT, the exact words that were looked for, and the sub-score assigned to it for each occurrence. Sub-scores were added together to generate the final score for the trial. Trials with scores greater than 2 were classified as combination therapy trials.

Field	Term	Score
title	“combine”, “combination”, “combining”	2
title	“with/without”, “and/or”	2
title	“plus”	2
title	“interaction”, “co-administered”	1
title	“and”, “with”	0.5
intervention	“plus”, “and”, “+”, “/”	1
intervention	“placebo”, “vehicle”	−1
summary	“combine”, “combination”, “combining”	2
summary	“together with”, “interaction with”, “alone or with”, “co-administered”, “parallel assignment”	1
arm	“combine”, “combination”, “combining”	2
arm	“together with”, “interaction with”, “alone or with”, “parallel assignment”, “plus”	1
arm	“Drug:” (frequency per individual arm)	1
keyword	“combination”	1