Table 1.
General characteristics of the GOLDN population.
| Men (n=448) | Women (n=488) | P | |
|---|---|---|---|
| Age, years | 49±16.3 | 49±16.3 | 0.559 |
| Weight, kg | 91±16.0 | 76±17.7 | <0.001 |
| Height, m | 1.78±0.73 | 1.65±0.70 | <0.001 |
| BMI, kg/m2 | 28.7±4.7 | 28.2±6.4 | 0.159 |
| Waist circumference, m | 1.01±0.13 | 0.93±0.19 | <0.001 |
| Hip circumference, m | 1.06±0.09 | 1.09±0.15 | 0.001 |
| Current smokers, n (%) | 36(8) | 38(8) | 0.904 |
| Current alcohol drinkers, n (%) | 224(50) | 255(52) | 0.513 |
| Systolic blood pressure, mmHg | 119±14.7 | 113±17.3 | <0.001 |
| Diastolic blood pressure, mmHg | 71±8.7 | 66±9.1 | <0.001 |
| Glucose, mmol/L | 5.77±1.05 | 5.39±0.91 | <0.001 |
| Log (Insulin, mU/L) | 1.10±0.21 | 1.07±0.21 | 0.040 |
| Total cholesterol, mmol/L | 4.94±0.95 | 4.99±1.07 | 0.449 |
| LDL cholesterol, mmol/L | 3.22±0.76 | 3.12±0.85 | 0.051 |
| HDL cholesterol, mmol/L | 1.07±0.25 | 1.35±0.36 | <0.001 |
| Triglycerides, mmol/L | 1.68±1.22 | 1.40±0.93 | <0.001 |
| Log (adiponectin, μg/L) | 3.73±0.24 | 3.96±0.23 | <0.001 |
| Obesity, n (%) | 149(33) | 169(35) | 0.679 |
| ADAM17 SNPs, n (%) | |||
| m1254A>G | |||
| AA | 287(64) | 328(67) | 0.335 |
| AG+GG | 161(36) | 160(33) | |
| i14121C>A | |||
| AA+AC | 131(29) | 128(26) | 0.307 |
| CC | 317(71) | 360(74) | |
| i33708A>G | |||
| AA | 179(40) | 206(42) | 0.732 |
| AG | 217(48) | 224(46) | |
| GG | 52(12) | 58(12) | |
| i48827A>C | |||
| AA | 224(50) | 222(46) | 0.300 |
| AC | 181(40) | 208(43) | |
| CC | 43(10) | 58(12) | |
| i53440C>T | |||
| CC | 115(26) | 115(24) | 0.699 |
| CT | 227(51) | 249(51) | |
| TT | 106(24) | 124(25) | |
| i62781G>T | |||
| GG | 134(30) | 148(30) | 0.369 |
| GT | 225(50) | 260(53) | |
| TT | 89(20) | 80(16) | |
All values are means ± SD.