Table 2.
Association between ADAM17 genetic variants and anthropometric variables and lipids.
| Variable | ADAM17_m1254A>G | ADAM17_i14121C>A | ADAM17_i33708A>G | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA (n=615) | AG+GG (n=321) | P* | CC (n=677) | CA+AA (n=259) | P* | AA (n=385) | AG (n=441) | GG (n=110) | P | |
| Weight, kg | 83±0.7 | 84±0.9 | 0.285 | 83±0.6 | 84±1.0 | 0.300 | 84±0.8 | 84±0.8 | 79±1.6 | 0.011 |
| Height, m | 1.72±0.01 | 1.70±0.01 | 0.017 | 1.71±0.01 | 1.72±0.01 | 0.023 | 1.71±0.01 | 1.71±0.01 | 1.71±0.01 | 0.734 |
| BMI, kg/m2 | 28.2±0.2 | 28.9±0.3 | 0.051 | 28.4±0.2 | 28.5±0.3 | 0.865 | 28.7±0.3 | 28.6±0.3 | 26.9±0.5 | 0.005 |
| Waist, m | 0.96±0.01 | 0.98±0.01 | 0.107 | 0.97±0.01 | 0.97±0.01 | 0.592 | 0.97±0.01 | 0.98±0.01 | 0.93±0.02 | 0.023 |
| Hip, m | 1.07±0.02 | 1.08±0.02 | 0.197 | 1.08±0.02 | 1.07±0.02 | 0.828 | 1.08±0.01 | 1.08±0.01 | 1.05±0.01 | 0.147 |
| Glucose, mmol/L | 5.56±0.03 | 5.61±0.04 | 0.342 | 5.54±0.03 | 5.68±0.05 | 0.023 | 5.61±0.04 | 5.61±0.03 | 5.44±0.07 | 0.141 |
| Log (Insulin, mU/L) | 1.07±0.01 | 1.11±0.01 | 0.016 | 1.08±0.01 | 1.09±0.01 | 0.617 | 1.08±0.01 | 1.10±0.01 | 1.06±0.02 | 0.240 |
| Total cholesterol, mmol/L | 4.98±0.03 | 4.94±0.05 | 0.483 | 4.99±0.03 | 4.94±0.05 | 0.603 | 4.96±0.04 | 4.96±0.04 | 5.04±0.08 | 0.620 |
| LDL cholesterol, mmol/L | 3.15±0.03 | 3.19±0.04 | 0.520 | 3.17±0.02 | 3.14±0.04 | 0.415 | 3.17±0.03 | 3.14±0.03 | 3.25±0.07 | 0.487 |
| HDL cholesterol, mmol/L | 1.24±0.01 | 1.19±0.01 | 0.027 | 1.22±0.01 | 1.22±0.01 | 0.796 | 1.22±0.01 | 1.22±0.01 | 1.24±0.02 | 0.627 |
| Triglycerides, mmol/L | 1.56±0.05 | 1.49±0.06 | 0.401 | 1.57±0.07 | 1.52±0.04 | 0.550 | 1.52±0.06 | 1.57±0.05 | 1.44±0.11 | 0.711 |
| Log (adiponectin, μg/L) | 3.86±0.01 | 3.85±0.01 | 0.565 | 3.86±0.01 | 3.83±0.01 | 0.041 | 3.86±0.01 | 3.85±0.01 | 3.87±0.02 | 0.612 |
| Variable | ADAM17_i48827A>C | ADAM17_i53440C>T | ||||||
|---|---|---|---|---|---|---|---|---|
| AA (n=446) | AC (n=389) | CC (n=101) | P | CC (n=230) | CT (n=476) | TT (n=230) | P | |
| Weight, Kg | 84±0.8 | 83±0.8 | 83±1.7 | 0.909 | 83±1.1 | 83±0.8 | 84±1.1 | 0.797 |
| Height, m | 1.71±0.01 | 1.71±0.01 | 1.71±0.01 | 0.533 | 1.72±0.01 | 1.71±0.01 | 1.70±0.01 | 0.040 |
| BMI, Kg/m2 | 28.5±0.3 | 28.5±0.3 | 28.4±0.5 | 0.974 | 28.1±0.4 | 28.5±0.3 | 28.9±0.4 | 0.292 |
| Waist, m | 0.97±0.01 | 0.96±0.01 | 0.95±0.02 | 0.512 | 0.96±0.01 | 0.97±0.01 | 0.97±0.02 | 0.903 |
| Hip, m | 1.08±0.01 | 1.07±0.01 | 1.07±0.02 | 0.661 | 1.08±0.01 | 1.07±0.01 | 1.08±0.02 | 0.657 |
| Glucose, mmol/L | 5.61±0.03 | 5.54±0.04 | 5.60±0.08 | 0.386 | 5.57±0.05 | 5.59±0.03 | 5.56±0.01 | 0.857 |
| Log (Insulin, mU/L) | 1.10±0.01 | 1.08±0.01 | 1.06±0.02 | 0.099 | 1.09±0.01 | 1.09±0.01 | 1.08±0.01 | 0.796 |
| Total cholesterol, mmol/L | 4.94±0.04 | 5.01±0.04 | 4.94±0.09 | 0.534 | 4.96±0.06 | 4.96±0.04 | 4.96±0.06 | 0.967 |
| LDL cholesterol, mmol/L | 3.17±0.03 | 3.19±0.03 | 3.09±0.07 | 0.552 | 3.16±0.05 | 3.17±0.03 | 3.17±0.05 | 0.980 |
| HDL cholesterol, mmol/L | 1.22±0.01 | 1.22±0.01 | 1.24±0.03 | 0.530 | 1.22±0.02 | 1.22±0.01 | 1.19±0.02 | 0.691 |
| Triglycerides, mmol/L | 1.51±0.05 | 1.56±0.06 | 1.54±0.12 | 0.810 | 1.56±0.08 | 1.52±0.05 | 1.53±0.08 | 0.916 |
| Log (adiponectin, μg/L) | 3.84±0.01 | 3.87±0.01 | 3.87±0.02 | 0.111 | 3.84±0.02 | 3.85±0.01 | 3.87±0.02 | 0.438 |
Values are mean±SE.
*
P values are adjusted for age, sex, smoking habit, alcohol consumption, diabetes, coronary heart disease, and family relationships.