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. Author manuscript; available in PMC: 2015 Mar 16.
Published in final edited form as: Acc Chem Res. 2011 Jun 29;44(12):1312–1319. doi: 10.1021/ar2000474

Figure 2. Folding pathway of the Tetrahymena ribozyme.

Figure 2

Time-resolved footprinting30,31 showed that tertiary interactions in the P4–P6 domain (green) form in ~1 s, more rapidly than contacts in peripheral helices (pink and grey) and in the P3–P9 domain (blue), due to mispairing of the P3 helix (gold).24 The ensemble of unfolded structures (U) partitions among parallel pathways, with 5–10% of molecules folding directly to the native state (N).25