Table 2.
Percent extraction efficiency of irinotecan and SN-38 from MCTS and culture medium tested at different concentration levels.
| Nominal concentration (nM) |
MCTS extracts | Nominal concentration (nM) |
Culture medium | ||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Concentration (mean±S.D.) (nM) |
Extraction efficiency (%) |
R.S.D. (%) | Concentration (mean±S.D.) (nM) |
Extraction efficiency (%) |
R.S.D. (%) | ||
| Irinotecan | Irinotecan | ||||||
| 2.5 | 2.01 ± 0.1 | 80.4 | 4.9 | 5.0 | 4.45 ± 0.52 | 89.0 | 11.7 |
| 250.0 | 226.3 ± 32.6 | 90.5 | 14.4 | 250.0 | 273.6 ± 37.0 | 109.4 | 13.5 |
| 5000.0 | 5550 ± 548.8 | 111.0 | 9.9 | 5000.0 | 4725.5 ± 396.2 | 94.5 | 8.4 |
| SN-38 | SN-38 | ||||||
| 2.5 | 2.06 ± 0.3 | 82.4 | 14.6 | 5.0 | 5.58 ± 0.78 | 111.6 | 14.0 |
| 250.0 | 225.8 ± 28.5 | 90.3 | 12.6 | 250.0 | 237.4 ± 32.5 | 95.0 | 13.7 |
| 500.0 | 469.5 ± 54.2 | 93.9 | 11.5 | 500,0 | 525.8 ± 45.9 | 105.2 | 8.7 |
S.D., standard deviation; R.S.D., relative standard deviation.