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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Surg Res. 2014 Nov 6;194(2):544–550. doi: 10.1016/j.jss.2014.10.056

Figure 1.

Figure 1

SAHA inhibits LPS-induced expression of iNOS and COX-2. Mice were given SAHA (50 mg/kg, i.p.) immediately after injection of LPS (20 mg/kg, i.p.). Livers were harvested 6 h after injection. (A) A representative image of a Western blot for iNOS and Cox-2 in liver homogenate from each group. (B) Graphic representation of relative abundance protein expression of iNOS and Cox-2 normalized to β-actin. (C) qRT-PCR analysis of relative mRNA levels of iNOS and Cox-2 in liver homogenate from each group. Data represent mean ± SEM from three independent experiments. Asterisks indicate a significant difference (*p<0.05) relative to livers treated with LPS in the absence of SAHA.