Figure 2.

Effect of MDMA on EEG activity. Animals were moving freely in a test chamber at temperature of 22 °C. A, Example of EEG traces represents basal activity (left panel) and vehicle injection (right panel). Time bar, 1 s; voltage bar, 0.25 mV. B, Example of traces represents basal activity (left panel) and 3 mg/kg MDMA injection (right panel). C, Representative analysis of power density in the frequency range between 0.5-30 Hz. Power density (μV²/Hz) is expressed as mean ± s.e.m (N = 6) on the y-axis plotted against EEG frequency (0.5 – 30 Hz) on the x-axis. Frequency bands (delta, alpha, theta and beta) are indicated by respective horizontal bars. D, Overall effect on EEG between 0 and 120 min. Injection of 3 mg/kg MDMA, but not 0.3 or 1 mg/kg, caused a reduction of power density in EEG activity over entire frequency (0.5 – 30 Hz, top) and individual bands [for instance, α-band (8 - 12 Hz, bottom)]. *P<0.05 vs. baseline, paired t-test. E, Time course of power density changes in α-band. Data are normalized to percentage (%) of baseline (± s.e.m; N = 6). *P<0.05 and **P<0.01 vs. saline control at respective time points. ANOVA followed by Scheffe test.