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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Oct 11;232(7):1245–1260. doi: 10.1007/s00213-014-3759-z

Figure 4.

Figure 4

Effect of MDMA on 5HT overflow in the brain. Animals were moving freely in a test chamber at temperature of 22 °C. A, 5HT overflow in the prefrontal cortex (PFC). Data are mean ± s.e.m. (N = 5-8). The time course of 5HT overflow is depicted in the line graph (left panel) and the mean overflow during the time period of 0-45 min is shown in the bar graph (right panel). B, 5HT overflow in the preoptic area (POA) of the anterior hypothalamus. Data are mean ± SEM (N = 6-7). Similarly, there was a dose- and time-dependent increase in the hypothalamic 5HT in response to MDMA injection (left panel). The bar graph shows the mean overflow during the time period of 0 - 45 min (right panel). *P<0.05, **P<0.01 and ***P<0.001 vs. saline control.