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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Oct 11;232(7):1245–1260. doi: 10.1007/s00213-014-3759-z

Figure 7.

Figure 7

Environmental factors altered the 5HT response to MDMA. Animals were placed on a treadmill at 22 or 32 °C and treadmill motor power was turned on during a time period of 0-30 min (see details in Methods section). Data are mean ± s.e.m (N = 4-8). A, Environmental factors had no effect on basal 5HT overflow. B, The effect of MDMA was not potentiated by physical stimulation or warm temperature alone. In contrast, a multifactorial combination potentiated MDMA-induced increases in the 5HT overflow. *P<0.05, **P<0.01vs. freely behaving rats at 22 °C.