. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Psychopharmacology (Berl). 2014 Oct 11;232(7):1245–1260. doi: 10.1007/s00213-014-3759-z

Table 1.

Pharmacologic intervention on hyperthermia induced by MDMA

	Dosage (mg/kg)	Potential targets	Maximum T_cor changes from baseline
saline	-	-	3.45 ±0.24 (5)
WAY100635	1	5HT_1AR	3.32 ±0.20 (4)
MK-801	0.1	NMDA-R	3.40 ±0.35 (4)
CGS19755	5	NMDA-R	0.83 ±0.35 (5)^***
hexamethonium	20	Ganglionic nAChR	1.05 ±0.10 (6)^*
methyllycaconitine	10	Central nAChR	3.20 ±0.15 (4)
midazolam	2	GABA_A-benzodiazepine-R	1.84 ±0.13 (4)^*

Data are mean ±S.E.M. and parentheses indicate numbers of animals in the group. Drug injection for intervention at specific receptor sites took place 30 min before MDMA administration. Drug dosages were expressed as mg/kg indicated in the second column. Dosage of MDMA was 3 mg/kg followed by 30-min physical activity on a treadmill at warm temperature of 32 °C.

P <0.05

P <0.01

^***

P <0.001 vs. saline+MDMA examined by unpaired Student t-test.