Table 2.
Genotype and minor allele frequencies of NCAM1-TTC12-ANKK1-DRD2 region loci.
| Polymorphism | Location | Genotypes N (%) | Allele Frequency | HWE p-value | |||
|---|---|---|---|---|---|---|---|
|
|
|
|
|
||||
| NCAM1 | |||||||
| rs618114 | Intron | GG | GA / AG | AA | G | A | 0.36 |
| Frequency | 254 (36.2) | 327 (46.6) | 120 (17.1) | 0.57 | 0.39 | ||
| TTC12 | |||||||
| rs2303380 | Intron | GG | GA / AG | AA | G | A | 0.61 |
| Frequency | 110 (15.3) | 334 (46.5) | 274 (38.2) | 0.38 | 0.60 | ||
| rs2282511 | Unknown | CC | CA / AC | AA | C | A | 0.15 |
| Frequency | 315 (44.2) | 304 (42.7) | 93 (13.1) | 0.64 | 0.33 | ||
| ANKK1 | |||||||
| rs877138 | Unknown | GG | GA / AG | AA | G | A | |
| Frequency | 94 (13.2) | 311 (43.6) | 309 (43.3) | 0.34 | 0.63 | 0.26 | |
| rs4938012 | Intron | GG | GA / AG | AA | G | A | 5.3 E-39 |
| Frequency | 0 (0.0) | 377 (61.3) | 238 (38.7) | 0.27 | 0.58 | ||
| rs17115439 | Synonymous | TT | TC / CT | CC | T | C | |
| Frequency | 94 (13.1) | 311 (43.4) | 311 (43.4) | 0.34 | 0.64 | 0.24 | |
| rs4938013 | Synonymous | CC | CA / AC | AA | C | A | |
| Frequency | 325 (44.8) | 312 (43.0) | 89 (12.3) | 0.66 | 0.33 | 0.29 | |
| rs4938015 | Intron | TT | TC / CT | CC | T | C | 0.21 |
| Frequency | 95 (13.3) | 310 (43.4) | 310 (43.4) | 0.34 | 0.63 | ||
| rs11604671 | Missense | GG | GA / AG | AA | G | A | 0.67 |
| Frequency | 189 (26.5) | 363 (50.8) | 162 (22.7) | 0.50 | 0.47 | ||
| rs1800497 | Missense | TT | TC / CT | CC | T | C | 0.91 |
| Frequency | 36 (5.0) | 248 (34.5) | 434 (60.4) | 0.22 | 0.76 | ||
| DRD2 | |||||||
| rs6277 | Synonymous | TT | TC / CT | CC | T | C | 0.51 |
| Frequency | 206 (28.5) | 351 (48.5) | 166 (23.0) | 0.52 | 0.47 | ||
| rs1079597 | Intron | GG | GA / AG | AA | G | A | 0.05 |
| Frequency | 490 (68.2) | 197 (27.4) | 32 (4.5) | 0.80 | 0.18 | ||
| rs1799732 | Upstream | Del/Del | C.Del/Del.C | CC | Del | C | 0.22 |
| Frequency | 0 (0.0) | 78 (11.0) | 634 (89.0) | 0.05 | 0.92 | ||
Note. Table shows the genotypes and frequencies for each marker (in order of chromosomal location). All loci are single nucleotide polymorphisms except for rs1799732 which is an InDel polymorphism. rs4938012 was dropped from further analyses due to Hardy Weinberg Equilibrium (HWE) failure. Functional classification determined using UCSC genome browser (https://genome.ucsc.edu/cgi-bin/hgGateway). Missing N(%). rs618114 33(4.5); rs2303380 16(2.2); rs2282511 22(3.0); rs877138 20(2.7); rs4938012 119(16.2); rs17115439 18(2.5); rs4938013 8(1.1); rs4938015 19(2.6); rs11604671 20(2.7); rs1800497 16(2.2); rs6277 11(1.5); rs1079597 15(2.0); rs1799732 22(3.0).