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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Neurochem. 2015 Feb 24;133(1):1–13. doi: 10.1111/jnc.13033

Figure 1. Potential dual role of Proline-directed Ser/Thr motifs in tau.

Figure 1

Tau contains 43 Proline residues in the human 441-residue isoform that could be modified by either PPIases or kinases. Many of these Prolines are grouped together in the Proline-rich domain between 151 and 244 αα. Within this domain, only 13 of the 23 Ser/Thr residues are known to be phosphorylated, suggesting that some of these sites may exist to regulate tau structure. PPIases could control both tau phosphorylation and tau structure leading to its oligomerization.