Table 3.

Association of soluble P-selectin Change in the ABI and Incident PAD^*

	Change in ABI Beta (95%CI)	p-value	Incident PAD HR (95%CI)	p-value
Demographics†	−0.008 (−0.011,−0.005)	<0.001	1.33 (1.14, 1.54)	<0.001
+Lifestyle and Comorbidities‡	−0.008 (−0.011, −0.004)	<0.001	1.31 (1.12, 1.53)	0.001
+Lipids, glucose, blood pressure§	−0.007 (−0.010, −0.003)	<0.001	1.28 (1.09, 1.50)	0.003
+CRP, IL-6, D-Dimer, Fibrinogen	−0.006 (−0.010, −0.003)	<0.001	1.30 (1.11, 1.53)	0.001

^*P-selectin per standard deviation (SD), which is 13.9 ng/mL; change in ABI from Exam 3 to Exam 5 modeled with growth curve analysis; incident PAD is defined as ABI≤0.90, excluding ABI>1.4 at Exam 3 or Exam 5, and prevalent PAD cases

^†Includes age, race, sex

^‡Adds ever smoker, BMI, hypertension, diabetes, estimated glomerular filtration rate

^§Adds HDL cholesterol, LDL cholesterol, triglycerides, glucose, systolic blood pressure, diastolic blood pressure