Figure 2. Schematic representation of the SLC9B1 gene.
(A): Analysis of the 5′ genomic region of the SLC9B1 gene in PromoterInspector software identified two putative promoters: promoter 1 and promoter 2. Analysis of the entire SLC9B1 gene in methyl primer express software reveals presence of two CpG islands: CpGI and CpGII. The position of the CpGI and CpGII relative to the intron/exon structure is indicated. The entire SLC9B1 gene is 118.81kb and has 12 exons (Ensemble gene ID: ENSG00000164037). (B) The positions of the putative SLC9B1 promoters and CpGI and CpGII are shown relative to the transcription start site TSS (+1). P1 is positioned at −500bp to +200bp while the P2 is located 27kb downstream of the TSS. CpGI is located at −23bp to +700bp and CpGII is located between exon1 and exon 2, 10kb downstream of the TSS. The translation start site, located in the second exon, is indicated as ATG.