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Necrosis predominates during cholestatic liver injury in man. Serum caspase-3 activities were measured in human patients and in galactosamine/endotoxin-treated mice (A). Full length cytokeratin 18 (FL-CK18) (M65 antigen values) and caspase-cleaved (cCK18) (M30 antigen values) were measured in serum of human patients (B). Patient data are presented in Table 1. *P<0.05 (versus control). #P<0.05 (versus UI patients).
