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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Dev Biol. 2015 Jan 31;400(1):72–81. doi: 10.1016/j.ydbio.2015.01.016

Figure 7. Model for the role of SNX5 and miR-216a in Notch signaling.

Figure 7

SNX5 (bound to Mib) moves to the site of Delta activation, where it binds to the membrane as Mib ubiquitylates Delta. SNX5 then facilitates membrane curvature and Delta endocytosis, which is required for cleavage of the Notch extracellular domain (NECD). Cleavage of the NECD frees the Notch intracellular domain (NICD) which is translocated to the nucleus to co-activate downstream target genes with the CSL transcription factor.