Table 1.
miRNA expression profiling in developing zebrafish eyes.
| 2 dpf | Fold Difference | p-value |
|---|---|---|
| miR-9 | 4.1791 | 0.0002 |
| miR-17-5p | 7.7904 | 0.0002 |
| miR-19a | 3.6866 | 0.0069 |
| miR-20 | 4.6253 | 0.0018 |
| miR-25 | 2.6127 | < 0.0001 |
| miR-31 | 3.3801 | 0.0008 |
| miR-93 | 3.7530 | 0.0002 |
| miR-108 | 4.1121 | 0.0033 |
| miR-124a | 7.0932 | < 0.0001 |
| miR-152 | 4.9246 | 0.0017 |
| miR-210 | 2.8556 | 0.0076 |
| miR-216 | 3.9684 | 0.0016 |
| 5 dpf | Fold Difference | p-value |
|---|---|---|
| miR-9 | 5.4529 | < 0.0001 |
| miR-17-5p | 7.1188 | < 0.0001 |
| miR-18 | 3.8517 | 0.0002 |
| miR-19a | 6.6342 | < 0.0001 |
| miR-19b | 3.9508 | < 0.0001 |
| miR-20 | 6.0296 | < 0.0001 |
| miR-22 | 5.6745 | < 0.0001 |
| miR-25 | 5.3233 | < 0.0001 |
| miR-31 | 3.4258 | 0.0001 |
| miR-93 | 5.2311 | < 0.0001 |
| miR-108 | 5.1436 | 0.001 |
| miR-124a | 7.3811 | < 0.0001 |
| miR-125b | 6.0221 | < 0.0001 |
| miR-152 | 4.0968 | < 0.0001 |
| miR-181a | 4.4360 | 0.0001 |
| miR-181b | 4.6483 | < 0.0001 |
| miR-182 | 5.4448 | < 0.0001 |
| miR-183 | 6.3569 | < 0.0001 |
| miR-204 | 7.9874 | < 0.0001 |
| miR-210 | 8.0629 | < 0.0001 |
| miR-213 | 3.8558 | < 0.0001 |
| miR-216 | 8.8500 | < 0.0001 |
| miR-217 | 6.8886 | 0.0002 |
Microarrays containing probes for 346 zebrafish miRNAs were performed on tissue from developing zebrafish retinas at 2 and 5 days post fertilization (dpf). Fold differences were calculated by dividing the normalized expression values by negative control signals derived from probes against a Pseudomonas aeruginsa dehydrogenase. All p-values were calculated based on paired t-tests.
*Fold difference is calculated by dividing the normalized miRNA expression by the negative control
**All p-values are calculated based on a paired t-test