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. 2015 Mar 1;25(3):269–277. doi: 10.1089/thy.2014.0476

FIG. 3.

FIG. 3.

Osteoarthritis (OA) pathology and scores in WT and D2KO mice. (A) High-powered views showing normal articular cartilage with an OARSI Score of zero in WT and D2KO mice. Scale bar=50 μm. sl, surface lamina; hac, hyaline articular cartilage; mf, mineralizing front; cc, calcified cartilage; scb, subchondral bone. (B) Maximum OA scores for WT (3=vertical clefts or erosions to the calcified cartilage extending to <25% of articular surface) and D2KO (4=vertical clefts or erosions to the calcified cartilage extending to 25–50% of articular surface) mice. (C) Graphs showing maximum OA scores in WT and D2KO mice; measures of cartilage damage (mean standardized OA score in red bars, mean erosion index in green bars); and mean subchondral bone area (BA/TA). Error bars represent standard error of the mean, with no significant differences among genotypes for all parameters. (D) Subchondral bone regions of interest in WT and D2KO mice.