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. 2015 Mar 16;11(3):e1004112. doi: 10.1371/journal.pcbi.1004112

Fig 4. Signal to noise ratio in PRC estimates.

Fig 4

PRCs were smoothed and normalized by the total charge of the injected pulse Q = I pulse ⋅ T pulse. Increasing the amplitude I pulse increased the estimates confidence (A-B), reducing the standard deviation of the PRC raw data points, especially as PCs fire at low firing rates. The plots display the PRC estimates obtained without the PID controller for I pulse = 50 and 100 pA, in the same PC over a comparable number of stimulation trials (i.e., 1911 and 1338 at high firing rates, and 3361 and 3350 at low firing rates, respectively). The smoothed PRCs and their 68% confidence intervals (C-D) are plotted, as a function of time (i.e., τ = (φ − 1) ⋅ ⟨ISI⟩) by the lines and shaded areas (i.e., dashed/gray for 50 pA and continuous/white for 100 pA).