Fig 6. Stochastic channel noise is not responsible for the firing rate dependency of the PRC.

The PRCs of the model incorporating channel noise (gray curves) are strikingly similar to those of the deterministic model (black curves). The variability of the spike trains does not affect the curves either at low (A and C) or high (B and D) firing rates (left and right columns, respectively). The membrane area of the model with channel noise was chosen to obtain the desired value of CV at low firing rate (around 10% for A, and 5% for C) and that same area was used for the simulations at high firing rate (panels B and D). Comparable values of CV were obtained in the deterministic model by changing the magnitude of the fluctuations of the injected current. For a given perturbation size, the model is less sensitive at high firing rates (B and D).