Table 1.
Comorbidity | No. studies | I2 statistic | Meta-analysis estimate (95% CI) |
---|---|---|---|
Autoimmune | |||
Overall | 1 | – | 1.26a |
Adrenocortical insufficiency | 1 | – | 0a |
Ankylosing spondylitis | 1 | – | 0.01a |
Celiac disease | 1 | – | 0.01a |
Derma/Polymyositis | 1 | – | 0a |
Diabetes Type 1 | 1 | – | 0a |
Guillain-Barré syndrome | 1 | – | – |
IBD | 1 | – | 0.01a |
Myasthenia gravis | 1 | – | 0.11a |
Pemphigoid/Pemphigus | 1 | – | 0.03a |
Polymyalgia rheumatica | 1 | – | 0.01a |
Primary biliary cirrhosis | 1 | – | 0.17a |
Psoriasis | 1 | – | 0.02a |
Purpura | 2 | 54.8 | 0.21 (0.087–0.33) |
Rheumatoid arthritis | 1 | – | 0.02a |
Sjögren’s syndrome | 1 | – | 0.02a |
SLE | 1 | – | 0.34a |
Systemic sclerosis | 4 | 89.9 | 0.17 (0–0.40) |
Vitiligo | 1 | – | 0a |
Wegener’s granulomatosis | 1 | – | 0.01a |
Cancer | |||
All types | 11 | 99.8 | 4.3 (2.67–6.1) |
Brain and nervous system | 8 | 97.0 | 0.27 (0.10–0.43) |
Breast | 9 | 99.2 | 1.6 (0.98–2.30) |
Bones and joints | 1 | – | 0.01 |
Digestive system | 9 | 99.0 | 1.05 (0.098–2.01) |
Thyroid | 3 | 92.1 | 0.056 (0–0.12) |
Eye and orbit | 3 | 0 | 0.033 (0.01–0.05) |
Female genital system | 8 | 95.7 | 0.95 (0.11–1.80) |
Cervical | 5 | 98.1 | 2.95 (0.005–0.58) |
Ovarian | 3 | 97.3 | 0.24 (0–0.54) |
Uterine | 5 | 97.4 | 0.29 (0.083–0.51) |
Endometrial | 1 | – | 0.65 |
Prostate | 7 | 98.7 | 0.94 (0.021–1.86) |
Testicular | 7 | 78.4 | 0.055 (0–0.12) |
Hematologic malignancies | 9 | 82.7 | 0.28 (0.16–0.40) |
Oral | 1 | – | 0.06a |
Lung | 10 | 94.8 | 0.12 (0.069–0.17) |
Skin | 6 | 98.6 | 0.61 (0.21–1.01) |
Melanoma | 3 | 98.0 | 0.22 (0–0.41) |
Non-melanoma | 5 | 98.9 | 0.60 (0.14–1.06) |
Urinary | 4 | 97.9 | 0.41 (0.10–0.72) |
Renal | 3 | 93.4 | 0.16 (0–0.36) |
Bladder | 2 | 96.8 | 0.28 (0–0.81) |
Cardiac arrhythmia | 2 | 96.6 | 0.89 (0.68–1.11) |
Cardiac valvular disease | 1 | – | 0.7a |
Chronic lung disease | 1 | – | 2.50a |
Congestive heart failure | 2 | 99.2 | 1.87 (0–3.80) |
Diabetes | 1 | – | 0.001a |
Epilepsy | 8 | 98.2 | 2.28 (1.11–3.44) |
Eye disease | |||
Cataracts | 1 | – | 2.08a |
Glaucoma | 1 | – | 1.26a |
Fibromyalgia | 1 | – | 0.12a |
Gastrointestinal | |||
Celiac disease | 1 | – | 0.01a |
Primary biliary cirrhosis | 1 | – | – |
Hypertension | 1 | – | 3.73a |
Stroke | 2 | 47.7 | 2.73 (2.51–2.95) |
Only one study therefore meta-analysis not possible. CI: confidence interval; IBD: inflammatory bowel disease; SLE: systemic lupus erythematosus.