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. 2015 Jan;21(1):22–34. doi: 10.1177/1352458514549398

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© The Author(s), 2015

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).

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Figure 1. — Trial design of CARE-MS I⁷ and CARE-MS II.⁸

In CARE-MS II, randomization into a third treatment arm (alemtuzumab 24 mg) was discontinued early and deemed exploratory for statistical purposes. CARE-MS: Comparison of Alemtuzumab and Rebif^® Efficacy in Multiple Sclerosis IFNβ-1a: interferon beta-1a; IV: intravenous; SC: subcutaneous.