Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
FLT3 mutations.
There are two types of FLT3 mutations, FLT3-ITD and FLT3-KDM. FLT3-ITD occurs between exons 14 and 15. When leukemia cells have FLT3-ITD, PCR products give a wild-type band and a larger ITD band (A). D835 and I836 codons are encoded by the nucleotide GATATC which forms the Eco RV restriction site. The amplified products of wild type FLT3 are digested to two bands by the Eco RV. When amplified products contain D835-mutations (FLT3-KDM), undigested bands are observed (B).
