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Structure and inhibitory activity of FLT3 inhibitors.
Tandutinib, Lestaurtinib and Midostaurin are first-generation FLT3 inhibitors. The second-generation FLT3 inhibitors, Sorafenib and Quizartinib, show clinical efficacy, while several problems regarding adverse effects and resistant mutations should be resolved before clinical use. Crenolanib is a recently developed FLT3 inhibitor, which is potent against both FLT3-ITD and FLT3-KDM.
