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Comparison of GI50 values of FLT3 inhibitors between FL absent and present conditions.
| FLT3 Inhibitors | GI50 value against MOLM14 (nM) | Inhibitory ratio | ||
|---|---|---|---|---|
| FL | 0 ng/mL | 10 ng/mL | ||
| Lestaurtinib | 3.3 | 6.8 | 2.1 | |
| Midostaurin | 7.2 | 25 | 3.5 | |
| Sorafenib | 3.3 | 12 | 3.6 | |
| Quizartinib | 0.38 | 1.3 | 3.4 | |
Addition of FL reduces the GI50 values of FLT3 inhibitors against human AML cell lines harboring FLT3-ITD, MOLM14.
