Table 1.

Risk of treatment interruption and supervision of frequency, place, method and supervisor

Subjects	Risk	Frequency	Method	Supervisor
Homeless people, alcohol or drug dependents, recurrent cases and patients with interruption history	High	Every day	Mandatory visit of patient to a clinic, hospital, pharmacy or public health center, and directly observed drug intake	Medical staff of clinic or hospital, pharmacist of pharmacy, or public health nurse at PHC
Solitary elderly, or institutionalized elderly requiring nursing care, etc	Medium	Once or twice a week	Visit of supervisor to patient’ home and confirmation through patient’s treatment card or counting empty drug bags	Public health nurse at PHCs
Elderly with families or in facility, etc	Low	Once or twice a month	Confirmation of adherence by telephone calls, FAX or e-mail to patient’ family or nursing staff of facility who confirms each dose of drugs with the patient’s treatment card or by counting empty drug bags	Patient’ family or nursing staff of facility
Employees	Low	Once a month	Confirmation of each dose of drugs through the patient’s treatment card or by counting empty drug bags. Patients receive drugs by prescription at pharmacy once a month.	Pharmacist of pharmacy