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. 2015 Mar 16;10(3):e0119028. doi: 10.1371/journal.pone.0119028

Fig 4. Flavaglines act upon a common pathway with insulin receptor signaling.

Fig 4

a-d. The average time-course of current development of cells pre-incubated with (full symbols) or without (empty symbols) FL23 (50 nM) for: (a) TRPM6V1393I (n≥8), (b) TRPM6K1584E (n≥7), (c) wild type TRPM6 together with Rac1T17N (n≥6) and (d) wild type TRPM6 together with Rac1G12V (n≥11). e. FL23 pre-incubation failed to alter currents in cells expressing TRPM6V1393I (n = 11), TRPM6K1584E (n≥8) and cells co-expressing wild type TRPM6 together with Rac1T17N (n = 8) and TRPM6 together with Rac1G12V (n≥14). Right panel shows current values normalized to each control condition. Stars indicate statistically significant difference (P<0.05) between vehicle- (white bar) and compound-treated cells (black bar).