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. 2015 Mar 16;10(3):e0120403. doi: 10.1371/journal.pone.0120403

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© 2015 Vogl et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — Distribution of the metabolic ratio (MR; concentration of 4’-hydroxyflurbiprofen [OHF] divided by the concentration of flurbiprofen [FLB]) measured in urine 2 h after administration of flurbiprofen to 283 individuals. Histograms are shown for the entire study group and for the genotypes with more than one individual. One single individual with genotype CYP2C9*3/*3 showed an MR of 0.096 (highlighted by an arrow in the histogram). The dashed lines indicate the best estimates of model-derived MRs, together with the FLB dose adjustment in percent of wild type *1/*1 (= 100%).