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. 2015 Mar 16;10(3):e0122447. doi: 10.1371/journal.pone.0122447

Fig 1. Factor VIII C2 domain-specific inhibitory antibody epitopes and membrane binding models.

Fig 1

(A) Ribbon diagram representation of the fVIII C2 domain bound to different classes of C2-specific inhibitory antibodies. Each X-ray crystal structure was superimposed with the C2 domain structure and residues involved in the different epitopes are shown by stick representation (red: fVIII C2 domain; green: G99 mAb, a non-classical BC epitope; blue/cyan: 3E6 mAb, a classical A epitope; yellow: BO2C11 mAb, a classical AB epitope). (B) Proposed PS membrane binding models for the fVIII C2 domain (left: old PS binding model, including the non-classical epitope with residues K2227 and V2223; right: new PS binding model, including both 3E6 and BO2C11 classical antibody epitopes, which centers at residue R2320).