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. 2015 Mar 16;10(3):e0122447. doi: 10.1371/journal.pone.0122447

Fig 2. X-ray crystal structure of the porcine factor VIII C2 domain.

Fig 2

(A) Ribbon diagram presentation of the 1.7 Å X-ray crystal structure. Displayed residues are solvent-exposed hydrophobic and basic residues proposed to interact with platelet surfaces. (B) Superposition of the human (pdb#: 1D7P, magenta) and porcine (pdb#: 4MO3, green) factor VIII C2 domain X-ray crystal structures. (3) Sequence alignment of human and porcine factor VIII C2 domains. Highlighted residues represent sequence differences (orange: 3E6 mAb binding region, blue: G99 mAb binding region, red: BO2C11 mAb binding region, cyan: G99 and BO2C11 binding region).