Table 3. Lymphocyte and monocyte activation markers, T reg lymphocytes and bacterial translocation markers at inclusion in patients with an increase or decrease of CD4+ T cells/mm3 during the follow-up with reference to the median.
| Patients with an increase of CD4 T cells lower than 10 / mm3 (n = 37) | Patients with an increase of CD4 T cells higher than 10 / mm3 (n = 33) | P | |
|---|---|---|---|
| General characteristics | |||
| Age (years) | 47 (43–49) | 45 (42–51) | 0,533 |
| Sex male (n, %) | 32 (87) | 27 (82) | 0,745 |
| HIV-related characteristics | |||
| Time of evolution of HIV infection (years) | 22 (19–26) | 22 (19–27) | 0,892 |
| CD4+ T cell/mm3 count at diagnosis | 188 (89–310) | 146 (80–209) | 0,380 |
| CD4+ T cell/mm3 count at inclusion | 381 (315–558) | 300 (197–395) | 0,008 |
| Time with undetectable HIV load (months) | 39 (14–62) | 48 (14–72) | 0,504 |
| Protease inhibitor based HAART (n, %) | 19 (52) | 19 (58) | 0,420 |
| Increase of CD4+ T cell/mm3 count from nadir until inclusion | 221 (57–344) | 168 (50–283) | 0,047 |
| Increase of CD4+ T cell/mm3 count during follow-up | -90 (-193; -31) | 110 (+40; +156) | 0,001 |
| HCV-related parameters | |||
| Patients with HCV coinfection (% of total of patients) | 29 (78) | 21 (64) | 0,196 |
| Patients with liver cirrhosis (% of total of patients) | 17 (46) | 8 (24) | 0,081 |
| Bacterial translocation | |||
| LBP (ng/ml) | 8 (6–12) | 12 (7–14) | 0,760 |
| Monocyte and lymphocyte derived parameters | |||
| CD14+TLR4+ cells (% of total CD14+ cells) | 84 (75–90) | 78 (63–87) | 0,188 |
| Serum soluble CD14 (x 100) (ng/ml) | 21 (16–27) | 19 (9–26) | 0,318 |
| Serum IL-6 (pg/ml) | 9 (3–15) | 5 (1–13) | 0,270 |
| CD4+ T cells (% of total lymphocytes) | 30 (18–37) | 25 (20–30) | 0,286 |
| CD4+DR+ cells (% of total CD4+T cells) | 17 (14–23) | 20 (15–35) | 0,870 |
| CD4+CD45RA+ cells (% of total CD4+T cells) | 32 (25–47) | 28 (18–41) | 0,215 |
| CD4+PD1+ cells (% of total CD4+T cells) | 26 (7–42) | 34 (10–76) | 0,299 |
| CD8+ T cells (% of total T cells) | 34 (26–43) | 42 (33–52) | 0,094 |
| CD8+DR+ cells (% of total CD8+T cells) | 32 (19–43) | 43 (37–55) | 0,174 |
| CD4/CD8 ratio | 0,8 (0,5–1,4) | 0,6 (0,4–1,0) | 0,278 |
| T regulatory cells number and function | |||
| CD4+CD25highCD127lowFoxP3+ (% of total CD4+T cells) | 7 (4–14) | 7 (2–11) | 0,580 |
| Serum TGF- β1 (pg/ml) | 69 (49–96) | 75 (58–115) | 0,265 |
Quantitative variables are expressed as median (interquartile range).