Local pharmacological manipulation of PTX-induced tics. A, B. Saline or PMPA (0.2 μg in 0.2 μl) was injected 10 min before PTX into the same DLS site. All animals received both treatments, separated by several days; n = 7 animals. C, D. Antagonism by cortical MUSC of tics evoked by PTX from DLS. All animals received both treatments, separated by several days; n = 5 animals. E. Dose-dependent antagonism by striatal MUSC of tics evoked by PTX from Cx (n=5). Post-hoc comparisons by 1-tailed t-test (uncorrected): *** p ≤ 0.0001; ** p < 0.005; * p < 0.025; † p ≤ 0.1. F. Ipsiversive rotations were seen after DLS MUSC; they were increased in the fourth session, after the 0.075 μg dose. No ipsiversive rotations were seen in the other conditions.