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. 2015 Mar 16;11(3):e1004682. doi: 10.1371/journal.ppat.1004682

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© 2015 Zhao et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — RdRp domains of the two structures have been displayed in the same orientation and the buried surfaces (indicated by the labeled interface residues) from the RdRp domains are relatively overlapping between the two NS5 structures. (A) and (B) Analysis of the electrostatic properties of the domain interfaces of the two NS5 structures. Positive surface charge is highlighted in red, negative charge in blue. (C) and (D) Analysis of the evolutionary conservation of the domain interfaces of the two NS5 structures. The color key indicates the degree of conservation, with cyan means highly variable and purple means highly conserved. (E) The relative orientations of the RdRp domain relative to the MTase domain in two structures in thin ribbon style. DENV3 NS5 is in blue, JEV NS5 is in green. “KDKE” highlights the MTase active site shown as mesh in purple and “GDD” for the RdRp active site shown as mesh. Residues at interface are highlighted and shown as dots. Linker (262–272) in DENV3 NS5 is shown as cartoon.