Fig 6. Label for Shank increased in the distal area of the PSD complex after depolarization with high K+.
Upon depolarization with high K+, labeling intensity with the pan Shank antibody at the PSD increased (B vs. A, Scale bar = 0.1 μm.) to ~150% of control values (C, data from [12]; three experiments, P<0.001, paired t-test). Histograms of distance measurement of label for Shank showed a shift to the right (E vs. D) with an increase in the median distance after high K+ (P<0.005, Wilcoxon rank-sum test).