Table 4. Analysis of association of the 27 SNPs gene polymorphism with the risk of KBD a .
| Gene/SNP | Genotype model b | Dominant model | Recessive model | Allele model c | ||
|---|---|---|---|---|---|---|
| AA | AB | BB | ||||
| OR (95% CI) | OR (95% CI) | OR | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| COL9A1 | ||||||
| rs592121 | 1.05(0.54–2.02) | 0.98 (0.67–1.43) | 1.00 | 1.04(0.74–1.48) | 1.26(0.69–2.30) | 1.01(0.76–1.32) |
| rs1064250 | 0.60 (0.22–1.64) | 1.19(0.82–1.75) | 1.00 | 1.12(0.78–1.59) | 1.20 (0.83–1.72) | 1.03 (0.75–1.40) |
| rs1135056 | 0.73 (0.36–1.50) | 1.25(0.86–1.82) | 1.00 | 0.99(0.70–1.40) | 2.13(1.17–3.82) d | 1.12 (0.85–1.46) |
| rs2274584 | 1.08 (0.50–2.34) | 1.27(0.85–1.87) | 1.00 | 1.21(0.85–1.73) | 1.04 (0.50–2.18) | 1.16 (0.85–1.57) |
| rs3806099 | 1.14 (0.59–2.18) | 0.99(0.68–1.45) | 1.00 | 1.08(0.76–1.52) | 1.36 (0.75–2.47) | 1.04 (0.78–1.36) |
| rs519068 | 0.94 (0.46–1.97) | 1.19(0.82–1.73) | 1.00 | 1.26(0.89–1.78) | 1.02 (0.51–2.05) | 1.07 (0.81–1.42) |
| rs617600 | 0.23 (0.04–1.21) | 1.04(0.69–1.59) | 1.00 | 1.01(0.68–1.50) | 0.30 (0.06–1.49) | 0.89 (0.61–1.28) |
| rs617985 | 0.23 (0.04–1.21) | 1.04(0.68–1.58) | 1.00 | 1.01(0.68–1.49) | 0.30 (0.06–1.48) | 0.88 (0.61–1.28) |
| rs679521 | 0.66 (0.39–1.09) | 0.85 (0.56–1.32) | 1.00 | 0.84(0.57–1.23) | 0.78 (0.52–1.16) | 0.81 (0.63–1.05) |
| rs6928611 | 0.00 (0.00-/) | 0.83(0.51–1.34) | 1.00 | 0.80(0.51–1.26) | 0.87 (0.55–1.37) | 0.73 (0.47–1.14) |
| rs2072650 | 0.56 (0.08–3.85) | 1.25(0.81–1.93) | 1.00 | 1.23(0.82–1.86) | 0.61 (0.10–3.65) | 1.15 (0.77–1.70) |
| rs12210870 | 0.00 (0.00-/) | 1.55(0.83–2.92) | 1.00 | 1.64(0.89–3.01) | 1.58 (0.86–2.91) | 1.60 (0.87–2.94) |
| rs6910140 | 0.48 (0.16–1.47) | 0.71(0.47–1.05) | 1.00 | 0.49(0.34–0.70) e | 0.37(0.13–1.05) | 0.73 (0.52–1.01) |
| rs883708 | 0.59 (0.15–2.35) | 1.07(0.70–1.64) | 1.00 | 1.08 (0.73–1.61) | 0.73 (0.19–2.73) | 1.01 (0.68–1.43) |
| rs616642 | 0.23 (0.04–1.21) | 1.03 (0.67–1.60) | 1.00 | 1.09 (0.72–1.63) | 0.30 (0.06–1.48) | 0.87 (0.59–1.27) |
| COL9A2 | ||||||
| rs12077871 | 0.50 (0.08–3.09) | 0.85(0.55–1.32) | 1.00 | 0.88 (0.58–1.32) | 0.61 (0.10–3.68) | 0.83 (0.56–1.23) |
| rs2076696 | 1.56 (0.69–3.51) | 1.22(0.84–1.77) | 1.00 | 1.25 (0.88–1.77) | 1.12 (0.53–2.37) | 1.22 (0.91–1.64) |
| rs209923 | 0.94 (0.54–1.66) | 0.86 (0.58–1.26) | 1.00 | 0.95 (0.67–1.34) | 1.07 (0.64–1.78) | 0.94 (0.72–1.22) |
| rs1983658 | 0.71 (0.41–1.22) | 0.76(0.51–1.14) | 1.00 | 0.81 (0.57–1.16) | 0.92 (0.57–1.48) | 0.82 (0.63–1.07) |
| rs3737821 | 0.44 (0.03–5.57) | 0.88(0.54–1.41) | 1.00 | 0.86 (0.55–1.36) | 0.45 (0.04–4.99) | 0.85 (0.55–1.32) |
| rs2075560 | 1.34 (0.45–4.02) | 0.86 (0.57–1.30) | 1.00 | 0.93 (0.63–1.37) | 1.36 (0.48–3.87) | 0.96 (0.67–1.36) |
| rs2273195 | 1.28(0.48–3.39) | 0.83 (0.55–1.23) | 1.00 | 0.90 (0.62–1.30) | 1.38 (0.55–3.43) | 0.93 (0.67–1.29) |
| rs2228567 | 0.99 (0.00-/) | 0.9 (0.61–1.12) | 1.00 | 1.08 (0.68–1.72) | 1.03 (0.64–1.64) | 1.07 (0.68–1.69) |
| COL9A3 | ||||||
| rs2249766 | 1.58 (0.78–3.23) | 1.37 (0.94–2.01) | 1.00 | 1.36 (0.96–1.93) | 1.28 (0.66–2.50) | 1.32 (0.99–1.77) |
| rs3765462 | 0.77 (0.21–2.85) | 1.59(1.05–2.42) d | 1.00 | 1.35 (0.91–1.98) | 0.51 (0.15–1.78) | 1.34 (0.94–1.92) |
| rs741758 | 1.36 (0.54–4.13) | 0.81 (0.55–1.22) | 1.00 | 0.88 (0.61–1.27) | 1.84 (0.62–5.46) | 0.92 (0.66–1.29) |
| rs760087 | 1.11 (0.64–1.91) | 0.79 (0.54–1.81) | 1.00 | 0.87 (0.61–1.25) | 1.35 (0.84–2.17) | 1.03 (0.77–1.29) |
a Adjusted for age and gender;
b AB stands for the minor/major alleles, BB as the reference genotype;
c Major allele as the reference allele;
d The significance did not remain after correction for multiple testing;
e The significance remained after correction for multiple testing.