Table 2. Multiple stepwise linear regression analysis of PFS-HR and the odds ratio for overall response.

		PFS-HR		Odds ratio for overall response
Factor		Regression coefficient (95% CI)	P	Regression coefficient (95% CI)	P
	Trial design (molecularly-selected vs. all-comer)	−0.42 (−0.67 to −0.18)	< 0.01	4.46 (2.52–6.39)	< 0.01
	Primary endpoint (PFS vs. other)	−0.31 (−0.56 to −0.53)	0.02	excluded
	Line of treatment (1st vs. other)	Excluded		excluded
	Year of trial initiation (before or in 2006 vs. 2007 or later)†	Excluded		excluded
	No. of randomized patients	Excluded		excluded
	Type of reporting (full text vs. abstract only)	Excluded		excluded

The threshold p values for entry into and removal from the model were 0.05 and 0.20, respectively.

†The cutoff level was set as the median year of trial initiation. PFS-HR, progression-free survival-hazard ratio; CI, confidence interval.